Cryptococcosis is caused by the type of
yeast called C. neoformans. It is found in the soil
every where, usually in association with bird
This Infection affects human beings through
inhalation. Lung infection goes unnoticed most of
the time. From lung, fungi spread to other parts of
the body. The patients present with disseminated
infection, especially meningo-encephalitis, face
mortality of about 12%.
Normally fungi does not affect normal persons.
Immune compromised patients i.e. HIV, Blood cancer
or those taking cancer chemotherapy or chronic
corticosteroid therapy, are susceptible to
Cryptococcosis. The most serious form of this
infection is cryptococcal meningitis.
Symptoms of Cryptococcosis - In the beginning
when the infection is localized in the lungs, it
could be mistaken as simple viral infection or
allergy. The patient presents with cough,
breathlessness or wheezing.
Otherwise symptoms are according to the organ
In case of cryptococcal meningitis, the patient has
nausea, vomiting, headache, confusion neck stiffness
Lumbar puncture (spinal tap) shows increased
pressure, increased WBC count, increased protein,
and decreased glucose. To see encapsulated
organisms, an India ink staining must be done.
For high risk patients - FUNGISOME® the
Liposomal Amphotericin B (1-3mg) is the drug of
choice. In case of Cryptococcal Meningitis where
hydrocephalus has developed, Ventricular shunting
may be needed. Other supportive and symptomatic
treatment is also needed. It can lead to permanent