|Amphotericin B has been the Gold Standard and broad-spectrum antifungal and antileishmanial since its discovery in mid 1950’s. In spite of the unmatched merits, technical limitations prevented development and use of Amphotericin B for topical applications.
Formulation development of Amphotericin B was limited because of extreme hydrophobicity and sparing solubility even in most organic solvents. Another hindrance was the fact that Amphotericin B is not absorbed through the skin. Difficulties in formulating and lack of prospects for transdermal delivery of Amphotericin B together discouraged efforts for development of its topical preparation(s).
FUNGISOME® Gel is uniquely designed Liposomal formulation of Amphotericin B that has overcome solubility problem and has enabled topical application. Amphotericin B containing multilamellar vesicles are converted into and stabilized as nanosomes in FUNGISOME® Gel. Nanosomes facilitate transport of Amphotericin B in these NDDS across stratum corneum because of favorable hydro-lipophylic micro-environment.
Owing to high affinity of Amphotericin B for ergosterol and its cellular precursors constituting fungal and leishmanial; membranes, Amphotericin B in the nanosomes of the FUNGISOME® Gel is transferred to these pathogenic cells causing their lysis.
The most intriguing question has been - Does Amphotericin B work on Dermatophytes?
FUNGISOME® Gel - a Nano-Liposomal Amphotericin B does.
Dermatophytes have ergosterol and activity of Amphotericin B on Dermatophytes has been made possible by strategic designing of FUNGISOME® Gel. In vitro studies revealed that Amphotericin B in FUNGISOME® Gel is effective against all common Dermatophytes Viz. epidermophyton, microsporum, trichophyton.
FUNGISOME® Gel is found to be effective and thus recommended for treatment of superficial fungal and leishmanial infections as below:
- Chronic and recurrent fungal infections including Dermatophytes
- Dressing after wound debridement
- Burn wound dressing
- Bed sores
- Around the tubes going inside body
- Vaginal candidiasis
- Diaper rashes
- Cutaneous leishmanial ulcers